• Product NameAlmorexant
• Brief DescriptionInhibitors
• Purification97.75%
• Biological ActivityAlmorexant(ACT078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively.
• Target NameOX Receptor antagonist
• CAS No. 871224-64-5
• Calculated MW 512.56
• Formulation C29H31F3N2O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Nervous system
  SMILES:CNC(=O)[C@@H](C1=CC=CC=C1)N2CCC3=CC(=C(C=C3[C@@H]2CCC4=CC=C(C=C4)C(F)(F)F)OC)OC
  Pathways:GPCR/G Protein; Neuroscience
  Receptor:OX1; OX2
  Boling pt:
  Melting pt:
  Solubility:DMSO: 10 mM
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Malherbe P, et al. Mol Pharmacol. 2009 Sep;76(3):618-31.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting