• Product NameGSK2606414
• Brief DescriptionInhibitors
• Purification99.50%
• Biological ActivityGSK2606414 is an orally available, potent, and selective PERK inhibitor with IC50 of 0.4 nM, displaying at least 100-fold selectivity over the other EIF2AKs assayed.
• Target NamePERK inhibitor
• CAS No. 1337531-36-8
• Calculated MW 451.44
• Formulation C24H20F3N5O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CN1C=C(C2=C1N=CN=C2N)C1=CC2=C(C=C1)N(CC2)C(=O)CC1=CC(=CC=C1)C(F)(F)F
  Pathways:Apoptosis
  Receptor:eIF-2AK1 (HRI); eIF-2AK2 (PKR); eIF-2AK3 (PERK)
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 19 mg/mL (42.08 mM); DMSO: 90 mg/mL (199.36 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Axten JM, et al. J Med Chem. 2012, 55(16), 7193-7207.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting