• Product NameFlavopiridol (Alvocidib) hydrochloride
• Brief DescriptionInhibitors
• Purification99.31%
• Biological ActivityFlavopiridol hydrochloride competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM.
• Target NameCDK inhibitor
• CAS No. 131740-09-5
• Calculated MW 438.3
• Formulation C21H21Cl2NO5
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CN1CC[C@@H]([C@@H](C1)O)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4Cl)O)O.Cl
  Pathways:Cell Cycle/Checkpoint
  Receptor:CDK1; CDK2; CDK4; CDK6; CDK7
  Boling pt:
  Melting pt:
  Solubility:DMSO: 88 mg/mL (200.77 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Caracciolo V, et al, Cell Cycle, 2012, 11(6), 1202-1216.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting