• Product NamePIK-93
• Brief DescriptionInhibitors
• Purification99.50%
• Biological ActivityPIK-93 is the first potent, synthetic PI4K (PI4KIIIβ) inhibitor with IC50 of 19 nM; shown to inhibit PI3Kα with IC50 of 39 nM.
• Target NameATM/ATR inhibitor; Carbonic Anhydrase inhibitor; DNA-PK inhibitor; HSV inhibitor; mTOR inhibitor; PI3K inhibitor
• CAS No. 593960-11-3
• Calculated MW 389.88
• Formulation C14H16ClN3O4S2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC(=O)NC1=NC(C)=C(S1)C1=CC(=C(Cl)C=C1)S(=O)(=O)NCCO
  Pathways:DNA Damage/DNA Repair; Metabolism; Microbiology&virology; PI3K/Akt/mTOR signaling
  Receptor:ATM; C2β; DNA-PK; hsVps34; mTORC1; p110α; p110β; p110γ; p110δ; PI3KIIIβ
  Boling pt:
  Melting pt:
  Solubility:DMSO: 78 mg/mL (200.06 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Knight ZA, Cell, 2006, 125(4), 733-747.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting