• Product NameSNS-314 Mesylate
• Brief DescriptionInhibitors
• Purification99.92%
• Biological ActivitySNS-314 Mesylate is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively. It is less potent to Trk A/B, Flt4, Fms, Axl, c-Raf and DDR2. Phase 1.
• Target NameAurora Kinase inhibitor
• CAS No. 1146618-41-8
• Calculated MW 527.04
• Formulation C18H15ClN6OS2CH4O3S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CS(O)(=O)=O.ClC1=CC=CC(NC(=O)NC2=NC=C(CCNC3=NC=NC4=C3SC=C4)S2)=C1
  Pathways:Cell Cycle/Checkpoint; Chromatin/Epigenetic
  Receptor:Aurora A; Aurora B; Aurora C
  Boling pt:
  Melting pt:
  Solubility:Water: 6 mg/mL (11.38 mM); DMSO: 105 mg/mL (199.22 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Oslob JD, et al. Bioorg Med Chem Lett, 2008, 18(17), 4880-4884.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting