• Product NameLGK-974
• Brief DescriptionInhibitors
• Purification99.16%
• Biological ActivityLGK-974 is a potent and specific PORCN inhibitor, and inhibits Wnt signaling with IC50 of 0.4 nM in TM3 cells. Phase 1.
• Target NamePorcupine inhibitor
• CAS No. 1243244-14-5
• Calculated MW 396.44
• Formulation C23H20N6O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC1=NC=CC(=C1)C1=C(C)C=C(CC(=O)NC2=NC=C(C=C2)C2=NC=CN=C2)C=N1
  Pathways:Stem Cells
  Receptor:Porcn
  Boling pt:
  Melting pt:
  Solubility:DMSO: 79 mg/mL warmed (199.27 mM)
  Appearance:Gray Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Liu J, et al. Proc Natl Acad Sci U S A. 2013, 110(50), 20224-20229.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting