• Product NameCH5132799
• Brief DescriptionInhibitors
• Purification99.87%
• Biological ActivityCH5132799 inhibits class I PI3Ks, particularly PI3Kα with IC50 of 14 nM; less potent to PI3Kβδγ, while sensitive in PIK3CA mutations cell lines. Phase 1.
• Target NamemTOR inhibitor; PI3K inhibitor
• CAS No. 1007207-67-1
• Calculated MW 377.42
• Formulation C15H19N7O3S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CS(=O)(=O)N1CCC2=C(N=C(N=C12)N1CCOCC1)C1=CN=C(N)N=C1
  Pathways:PI3K/Akt/mTOR signaling
  Receptor:mTOR; PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ
  Boling pt:
  Melting pt:
  Solubility:DMSO: 12 mg/mL (31.79 mM)
  Appearance:Gray Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Tanaka H, et al, Clin Y Res, 2011, 17(10), 3272-3281.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting