• Product NameG-749
• Brief DescriptionInhibitors
• Purification99.24%
• Biological ActivityG-749 is a novel and potent FLT3 inhibitor with IC50 of 0.4 nM, 0.6 nM and 1 nM for FLT3 (WT), FLT3 (D835Y), and Mer, respectively, showing lower potency against other tyrosine kinases.
• Target NameAurora Kinase inhibitor; c-RET inhibitor; FLT inhibitor; TAM Receptor inhibitor
• CAS No. 1457983-28-6
• Calculated MW 521.41
• Formulation C25H25BrN6O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cardiovascular System
  SMILES:CN1CCC(CC1)NC1=NC2=C(C(=O)NC=C2Br)C(NC2=CC=C(OC3=CC=CC=C3)C=C2)=N1
  Pathways:Cell Cycle/Checkpoint; Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors; Chromatin/Epigenetic
  Receptor:Aurora B; RET; FLT3; FLT3 (D835Y); Mer
  Boling pt:
  Melting pt:
  Solubility:DMSO: 24 mg/mL warmed (46.02 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Lee HK, et al. Blood. 2014, 123(14), 2209-2219.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting