• Product NamePD 98059
• Brief DescriptionInhibitors
• Purification99.50%
• Biological ActivityPD98059 is a non-ATP competitive MEK inhibitor with IC50 of 2 μM in a cell-free assay, specifically inhibits MEK-1-mediated activation of MAPK; does not directly inhibit ERK1 or ERK2.
• Target NameMEK inhibitor
• CAS No. 167869-21-8
• Calculated MW 267.28
• Formulation C16H13NO3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:COC1=CC=CC(=C1N)C1=CC(=O)C2=CC=CC=C2O1
  Pathways:MAPK
  Receptor:MEK1
  Boling pt:
  Melting pt:
  Solubility:DMSO: 14 mg/mL warmed (52.37 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Dudley DT, et al. Proc Natl Acad Sci U S A, 1995, 92(17), 7686-7689.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting