• Product NameOSI 930
• Brief DescriptionInhibitors
• Purification99.76%
• Biological ActivityOSI-930 is a potent inhibitor of Kit, KDR and CSF-1R with IC50 of 80 nM, 9 nM and 15 nM, respectively; also potent to Flt-1, c-Raf and Lck and low activity against PDGFRα/β, Flt-3 and Abl. Phase 1.
• Target NameCSF-1R inhibitor; FLT inhibitor; Raf inhibitor; Src inhibitor; VEGFR inhibitor
• CAS No. 728033-96-3
• Calculated MW 443.44
• Formulation C22H16F3N3O2S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:FC(F)(F)OC1=CC=C(NC(=O)C2=C(NCC3=CC=NC4=CC=CC=C34)C=CS2)C=C1
  Pathways:Angiogenesis; MAPK; Tyrosine Kinase/Adaptors
  Receptor:CSF-1R; FLT1; C-Raf; Lck; VEGFR2?(KDR)
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 3 mg/mL (6.76 mM); DMSO: 89 mg/mL (200.7 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Garton AJ, et al. Y Res. 2006, 66(2):1015-1024.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting