• Product NameMK0752
• Brief DescriptionInhibitors
• Purification99.19%
• Biological ActivityMK-0752 is a moderately potent γ-secretase inhibitor, which reduces Aβ40 production with IC50 of 5 nM. Phase 1/2.
• Target NameBeta Amyloid inhibitor
• CAS No. 471905-41-6
• Calculated MW 442.9
• Formulation C21H21ClF2O4S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Nervous system
  SMILES:OC(=O)CCC1CCC(CC1)(C1=C(F)C=CC(F)=C1)S(=O)(=O)C1=CC=C(Cl)C=C1
  Pathways:Neuroscience
  Receptor:Aβ
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 45 mg/mL (101.6 mM); DMSO: 89 mg/mL (200.94 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Cook JJ, et al. J Neurosci, 2010, 30(19), 6743-6750.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting