• Product NamePoziotinib (HM781-36B)
• Brief DescriptionInhibitors
• Purification99.78%
• Biological ActivityPoziotinib(NOV120101; HM781-36B) is an irreversible Pan-HER inhibitor with IC50s of 3/5/23 nM for HER1/HER2/HER4 respectively.
• Target NameHER inhibitor
• CAS No. 1092364-38-9
• Calculated MW 491.34
• Formulation C23H21Cl2FN4O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:COC1=C(OC2CCN(CC2)C(=O)C=C)C=C2C(NC3=C(F)C(Cl)=C(Cl)C=C3)=NC=NC2=C1
  Pathways:Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
  Receptor:HER1; HER2; HER4
  Boling pt:
  Melting pt:
  Solubility:DMSO: 98 mg/mL (199.45 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Nam HJ, et al. Y Lett. 2011 Mar 28;302(2):155-65.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting