• Product NameA-1210477
• Brief DescriptionInhibitors
• Purification99.21%
• Biological ActivityA-1210477 is a potent and selective MCL-1 and Bcl-2 inhibitor with Ki and IC50 of 0.454 nM and 26.2 nM, respectively, >100-fold selectivity over other Bcl-2 family members.
• Target NameBCL inhibitor
• CAS No. 1668553-26-1
• Calculated MW 850.04
• Formulation C46H55N7O7S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CN(C)S(=O)(=O)N1CCN(CC1)C1=CC=C(OCC2=C(C(C)=NN2C)C2=CC=CC3=C2N(CCN2CCOCC2)C(C(O)=O)=C3CCCOC2=CC=CC3=CC=CC=C23)C=C1
  Pathways:Apoptosis
  Receptor:Mcl-1
  Boling pt:
  Melting pt:
  Solubility:DMSO: 10 mM
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Bruncko M, et al. J Med Chem. 2015 Mar 12;58(5):2180-2194.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting