• Product NameGSK429286A
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityGSK429286A is a selective inhibitor of ROCK1 and ROCK2 with IC50 of 14 nM and 63 nM, respectively.
• Target NameROCK inhibitor
• CAS No. 864082-47-3
• Calculated MW 432.37
• Formulation C21H16F4N4O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC1=C(C(CC(=O)N1)C1=CC=C(C=C1)C(F)(F)F)C(=O)NC1=C(F)C=C2NN=CC2=C1
  Pathways:Cell Cycle/Checkpoint; Stem Cells
  Receptor:ROCK1; ROCK2
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 4 mg/mL (9.25 mM); DMSO: 87 mg/mL (201.21 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Goodman KB, et al. J Med Chem, 2007, 50(1), 6-9.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting