• Product NameRO 3280
• Brief DescriptionInhibitors
• Purification99.50%
• Biological ActivityRO3280 is a potent, highly selective inhibitor of Polo-like kinase 1 (PLK1) with IC50 of 3?nM.
• Target NamePLK inhibitor
• CAS No. 1062243-51-9
• Calculated MW 543.61
• Formulation C27H35F2N7O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:COC1=C(NC2=NC=C3N(C)C(=O)C(F)(F)CN(C4CCCC4)C3=N2)C=CC(=C1)C(=O)NC1CCN(C)CC1
  Pathways:Cell Cycle/Checkpoint
  Receptor:PLK1
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 100 mg/mL (183.95 mM); DMSO: 100 mg/mL (183.95 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Chen S, et al. Bioorg Med Chem Lett, 2012, 22(2), 1247-1250.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting