• Product NameGandotinib (LY2784544)
• Brief DescriptionInhibitors
• Purification99.79%
• Biological ActivityLY2784544(gandotinib) is a potent JAK2 inhibitor with IC50 of 3 nM, effective in JAK2V617F(Ki=0.245 nM), 8- and 20-fold selective versus JAK1 and JAK3.
• Target NameFLT inhibitor; JAK inhibitor
• CAS No. 1229236-86-5
• Calculated MW 469.94
• Formulation C23H25ClFN7O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC1=CC(NC2=NN3C(CC4=C(F)C=C(Cl)C=C4)=C(C)N=C3C(CN3CCOCC3)=C2)=NN1
  Pathways:Angiogenesis; Chromatin/Epigenetic; Tyrosine Kinase/Adaptors; JAK/STAT signaling; Stem Cells
  Receptor:FLT3; JAK1; JAK2; JAK2; JAK2 (V617F)
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 9 mg/mL (19.15 mM); DMSO: 94 mg/mL (200.02 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Ma L, et al. 53rd ASH Annual Meeting and Exposition, 2011, Abstract 4087.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting