• Product NameKRCA-0008
• Brief DescriptionInhibitors
• Purification99.64%
• Biological ActivityKRCA-0008 is a potent and selective ALK/Ack1 inhibitor with IC50 of 12 nM/4 nM for ALK and Ack1 respectively; displays drug-like properties without hERG liability.
• Target NameACK inhibitor; ALK inhibitor
• CAS No. 1472795-20-2
• Calculated MW 609.12
• Formulation C30H37ClN8O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Immunology
  SMILES:COC1=C(NC2=NC=C(Cl)C(NC3=C(OC)C=C(C=C3)N3CCN(CC3)C(C)=O)=N2)C=CC(=C1)N1CCN(CC1)C(C)=O
  Pathways:Angiogenesis; Neuroscience; Tyrosine Kinase/Adaptors
  Receptor:ACK; ALK
  Boling pt:
  Melting pt:
  Solubility:DMSO: 10 mM
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Park CH, et al. Bioorg Med Chem Lett. 2013 Nov 15;23(22):6192-6.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting