• Product NamePD173074
• Brief DescriptionInhibitors
• Purification99.33%
• Biological ActivityPD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM in cell-free assays, ~1000-fold selective for FGFR1 than PDGFR and c-Src.
• Target NameEGFR inhibitor; FGFR inhibitor; IGF-1R inhibitor; Src inhibitor; VEGFR inhibitor
• CAS No. 219580-11-7
• Calculated MW 523.67
• Formulation C28H41N7O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CCN(CC)CCCCNC1=NC2=NC(NC(=O)NC(C)(C)C)=C(C=C2C=N1)C1=CC(OC)=CC(OC)=C1
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors; JAK/STAT signaling
  Receptor:EGFR; FGFR1; Insulin Receptor; c-Src; VEGFR2
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 100 mg/mL (190.95 mM); DMSO: 100 mg/mL (190.95 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Mohammadi M, et al. EMBO J, 1998, 17(20), 5896-5904.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting