• Product NameMK-8245
• Brief DescriptionInhibitors
• Purification98.77%
• Biological ActivityMK-8245 is an liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with anti-diabetic and anti-dyslipidemic efficacy. Phase 2.
• Target NameDehydrogenase inhibitor
• CAS No. 1030612-90-8
• Calculated MW 467.25
• Formulation C17H16BrFN6O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Metabolism system
  SMILES:OC(=O)CN1N=NC(=N1)C1=CC(=NO1)N1CCC(CC1)OC1=C(Br)C=CC(F)=C1
  Pathways:Metabolism
  Receptor:SCD1 (human); SCD1 (mouse); SCD1 (rat)
  Boling pt:
  Melting pt:
  Solubility:DMSO: 93 mg/mL (199.03 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Oballa RM, et al. J Med Chem, 2011, 54(14), 5082-5096.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting