• Product NameIWR-1-endo
• Brief DescriptionInhibitors
• Purification99.19%
• Biological ActivityIWR-1(IWR-1-endo) is a novel small-molecule inhibitor of Wnt signaling by stabilizing the Axin destruction complex with an EC50 of 0.2 uM.
• Target NameWnt/beta-catenin inhibitor
• CAS No. 1127442-82-3
• Calculated MW 409.44
• Formulation C25H19N3O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:C1[C@@H]2C=C[C@H]1[C@@H]3[C@H]2C(=O)N(C3=O)C4=CC=C(C=C4)C(=O)NC5=CC=CC6=C5N=CC=C6
  Pathways:Cytoskeletal Signaling; Stem Cells
  Receptor:Wnt
  Boling pt:
  Melting pt:
  Solubility:DMSO: 30 mg/mL (73.27 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Lu J, et al. Bioorg Med Chem Lett, 2009, 19(14), 3825-3827.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting