• Product NameGSK2656157
• Brief DescriptionInhibitors
• Purification99.50%
• Biological ActivityGSK2656157 is an ATP-competitive and highly selective inhibitor of PERK with IC50 of 0.9 nM in a cell-free assay, 500-fold greater against a panel of 300 kinases.
• Target NameERK inhibitor
• CAS No. 1337532-29-2
• Calculated MW 416.45
• Formulation C23H21FN6O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CN1C=C(C2=C1N=CN=C2N)C1=C(F)C2=C(C=C1)N(CC2)C(=O)CC1=CC=CC(C)=N1
  Pathways:MAPK
  Receptor:PERK
  Boling pt:
  Melting pt:
  Solubility:DMSO: 32 mg/mL (76.83 mM)
  Appearance:Off-white Color Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Atkins C, et al. Y Res, 2013, 73(6), 1993-2002.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting