• Product NameCEP37440
• Brief DescriptionInhibitors
• Purification99.92%
• Biological ActivityCEP-37440 is a novel potent and selective Dual FAK/ALK inhibitor with IC50 s of 2.3 nM (FAK) and 120 nM(ALK cellular IC50 in 75% human plasma).
• Target NameALK inhibitor; FAK inhibitor
• CAS No. 1391712-60-9
• Calculated MW 580.12
• Formulation C30H38ClN7O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Immunology
  SMILES:CNC(=O)C1=CC=CC=C1NC2=NC(=NC=C2Cl)NC3=C(C4=C(C[C@H](CCC4)N5CCN(CC5)CCO)C=C3)OC
  Pathways:Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
  Receptor:ALK; FAK
  Boling pt:
  Melting pt:
  Solubility:DMSO: 10 mM
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Iragavarapu C, et al. J Hematol Oncol. 2015 Feb 27;8(1):17.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting