• Product NameGW 2580
• Brief DescriptionInhibitors
• Purification99.50%
• Biological ActivityGW2580 is an orally bioavailable inhibitor of c-FMS kinase; completely inhibited human cFMS kinase in vitro at 0.06 microM and was inactive against 26 other kinases.
• Target Namec-Fms inhibitor
• CAS No. 870483-87-7
• Calculated MW 366.41
• Formulation C20H22N4O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:COC1=CC=C(COC2=C(OC)C=C(CC3=CN=C(N)N=C3N)C=C2)C=C1
  Pathways:Tyrosine Kinase/Adaptors
  Receptor:c-Fms
  Boling pt:
  Melting pt:
  Solubility:DMSO: 48 mg/mL (131.0 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Conway JG, et al. Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):16078-83.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting