• Product NameIC-87114
• Brief DescriptionInhibitors
• Purification99.50%
• Biological ActivityIC-87114 is a selective PI3Kδ inhibitor with IC50 of 0.5 μM in a cell-free assay, 58-fold more selective for PI3Kδ than PI3Kγ, and over 100-fold more selective than PI3Kα/β.
• Target NamePI3K inhibitor
• CAS No. 371242-69-2
• Calculated MW 397.43
• Formulation C22H19N7O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC1=CC=CC=C1N1C(CN2C=NC3=C2N=CN=C3N)=NC2=CC=CC(C)=C2C1=O
  Pathways:PI3K/Akt/mTOR signaling
  Receptor:PI3Kβ; PI3Kγ; PI3Kδ
  Boling pt:
  Melting pt:
  Solubility:DMSO: 0.66 mg/mL (1.66 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Wen PJ, et al. Nat Commun, 2011, doi:10.1038/ncomms1500.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting