• Product NameTGX-221
• Brief DescriptionInhibitors
• Purification99.50%
• Biological ActivityTGX-221 is a p110β-specific inhibitor with IC50 of 5 nM in a cell-free assay, 1000-fold more selective for p110β than p110α.
• Target NamePI3K inhibitor
• CAS No. 663619-89-4
• Calculated MW 364.44
• Formulation C21H24N4O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC(NC1=CC=CC=C1)C1=CC(C)=CN2C(=O)C=C(N=C12)N1CCOCC1
  Pathways:PI3K/Akt/mTOR signaling
  Receptor:p110α; p110β; p110γ; p110δ
  Boling pt:
  Melting pt:
  Solubility:DMSO: 12 mg/mL (32.92 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Chaussade C, et al. Biochem J. 2007, 404(3), 449-458.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting