• Product NameTaladegib
• Brief DescriptionInhibitors
• Purification99.50%
• Biological ActivityTaladegib (LY2940680) binds to the Smoothened (Smo) receptor and potently inhibits Hedgehog (Hh) signaling. Phase 1/2.
• Target NameHedgehog/Smoothened antagonist
• CAS No. 1258861-20-9
• Calculated MW 512.5
• Formulation C26H24F4N6O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CN(C1CCN(CC1)C1=NN=C(C2=CC=NN2C)C2=CC=CC=C12)C(=O)C1=C(C=C(F)C=C1)C(F)(F)F
  Pathways:GPCR/G Protein; Stem Cells
  Receptor:Smoothened
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 2 mg/mL (3.9 mM); DMSO: 0.66 mg/mL (1.28 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Redmond EM et al. Expert Opin Investig Drugs, 2011, 20(12),1649-1664.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting