• Product NameJNK-IN-8
• Brief DescriptionInhibitors
• Purification99.50%
• Biological ActivityJNK-IN-8 is the first irreversible JNK inhibitor for JNK1, JNK2 and JNK4 with IC50 of 4.7 nM, 18.7 nM and 1 nM, >10-fold selectivity against MNK2, Fms and no inhibition to c-Kit, Met, PDGFRβin A375 cell line.
• Target Namec-Kit inhibitor; JNK inhibitor
• CAS No. 1410880-22-6
• Calculated MW 507.59
• Formulation C29H29N7O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC1=C(C=CC(=C1)NC(=O)C2=CC(=CC=C2)NC(=O)/C=C/CN(C)C)NC3=NC=CC(=N3)C4=CN=CC=C4
  Pathways:MAPK; Tyrosine Kinase/Adaptors
  Receptor:Kit (V559D); Kit (V559D,T670I); JNK1; JNK2; JNK3
  Boling pt:
  Melting pt:
  Solubility:DMSO: 100 mg/mL warmed (197.0 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Zhang T, et al. Chem Biol, 2012, 19(1), 140-154.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting