• Product NameML167
• Brief DescriptionInhibitors
• Purification99.50%
• Biological ActivityML167 is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor with IC50 of 136 nM, >10-fold selectivity for closely related kinases Clk1-3 and Dyrk1A/1B.
• Target NameCDK inhibitor; DYRK inhibitor
• CAS No. 1285702-20-6
• Calculated MW 335.36
• Formulation C19H17N3O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC1=CC=C(CNC2=NC=NC3=C2C=C(C=C3)C2=CC=C(CO)O2)O1
  Pathways:Cell Cycle/Checkpoint
  Receptor:CLK1; CLK2; CLK4; Dyrk1B
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 13 mg/mL warmed (38.76 mM); DMSO: 67 mg/mL (199.78 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Rosenthal AS, et al. Probe Reports from the NIH Molecular Libraries Program. 2010.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting