• Product NameTG100-115
• Brief DescriptionInhibitors
• Purification99.89%
• Biological ActivityTG100-115 is a PI3Kγ/δ inhibitor with IC50 of 83 nM/235 nM, with little effect on PI3Kα/β. Phase 1/2.
• Target NamePI3K inhibitor
• CAS No. 677297-51-7
• Calculated MW 346.34
• Formulation C18H14N6O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:NC1=NC2=C(N=C(C3=CC(O)=CC=C3)C(=N2)C2=CC(O)=CC=C2)C(N)=N1
  Pathways:PI3K/Akt/mTOR signaling
  Receptor:PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ
  Boling pt:
  Melting pt:
  Solubility:DMSO: 9 mg/mL (25.98 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Doukas J, et al. Proc Natl Acad Sci U S A, 2006, 103(52), 19866-19871.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting