• Product NamePF-04217903
• Brief DescriptionInhibitors
• Purification98.41%
• Biological ActivityPF-04217903 is a selective ATP-competitive c-Met inhibitor with IC50 of 4.8 nM in A549 cell line, susceptible to oncogenic mutations (no activity to Y1230C mutant). Phase 1.
• Target Namec-Met/HGFR inhibitor
• CAS No. 956905-27-4
• Calculated MW 372.38
• Formulation C19H16N8O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:OCCN1C=C(C=N1)C1=CN=C2N=NN(CC3=CC4=C(C=C3)N=CC=C4)C2=N1
  Pathways:Tyrosine Kinase/Adaptors
  Receptor:c-Met
  Boling pt:
  Melting pt:
  Solubility:DMSO: 5 mg/mL (13.42 mM)
  Appearance:Gray-Brown Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Timofeevski SL, et al. Biochemistry, 2009, 48(23), 5339-5349.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting