• Product NameBMS-265246
• Brief DescriptionInhibitors
• Purification99.55%
• Biological ActivityBMS-265246 is a potent and selective CDK1/2 inhibitor with IC50 of 6 nM/9 nM in a cell-free assay. It is 25-fold more selective for CDK1/2 than CDK4.
• Target NameCDK inhibitor
• CAS No. 582315-72-8
• Calculated MW 345.34
• Formulation C18H17F2N3O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CCCCOC1=C2C=NNC2=NC=C1C(=O)C1=C(F)C=C(C)C=C1F
  Pathways:Cell Cycle/Checkpoint
  Receptor:CDK1/CyclinB; CDK2/CyclinE; CDK4/CyclinD
  Boling pt:
  Melting pt:
  Solubility:DMSO: 20 mg/mL (57.91 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Misra RN, et al. Bioorg Med Chem Lett. 2003, 13(14), 2405-2408.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting