• Product NameKU55933
• Brief DescriptionInhibitors
• Purification98.27%
• Biological ActivityKU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor with IC50/Ki of 12.9 nM/2.2 nM in cell-free assays, and is highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR.
• Target NameATM/ATR inhibitor; DNA-PK inhibitor; mTOR inhibitor; PI3K inhibitor
• CAS No. 587871-26-9
• Calculated MW 395.49
• Formulation C21H17NO3S2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:O=C1C=C(OC(=C1)C1=C2SC3=CC=CC=C3SC2=CC=C1)N1CCOCC1
  Pathways:DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
  Receptor:ATM; ATR; DNA-PK; mTOR; PI3K
  Boling pt:
  Melting pt:
  Solubility:DMSO: 33 mg/mL (83.44 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Hickson I, et al. Y Res. 2004, 64(24), 9152-9159.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting