• Product NameAZ 3146
• Brief DescriptionInhibitors
• Purification99.50%
• Biological ActivityAZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM, contributes to recruitment of CENP-E (kinesin-related motor protein), less potent to FAK, JNK1, JNK2, and Kit.
• Target NameKinesin inhibitor
• CAS No. 1124329-14-1
• Calculated MW 452.55
• Formulation C24H32N6O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:COC1=C(NC2=NC=C3N(C)C(=O)N(C4CCCC4)C3=N2)C=CC(OC2CCN(C)CC2)=C1
  Pathways:Cytoskeletal Signaling
  Receptor:Mps1
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 91 mg/mL (201.08 mM); DMSO: 28 mg/mL (61.87 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Hewitt L, et al. J Cell Biol, 2010, 190(1), 25-34.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting