• Product NameTBB(NSC 231634)
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityTBB(NSC 231634) is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2)with IC50s of 0.9 and 1.6 μM for rat liver and human recombinant CK2 respectively).
• Target NameCasein Kinase inhibitor; CDK inhibitor; GSK-3 inhibitor
• CAS No. 17374-26-4
• Calculated MW 434.71
• Formulation C6HBr4N3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:BrC1=C(Br)C(Br)=C(Br)C2=NNN=C12
  Pathways:Metabolism; PI3K/Akt/mTOR signaling; Cell Cycle/Checkpoint; Stem Cells
  Receptor:CK2; CDK2; GSK-3β
  Boling pt:
  Melting pt:
  Solubility:DMSO, Ethanol: 100 mM
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Orzechowska E, et al. Oncol Rep. 2012 Jan;27(1):281-5.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting