• Product NamePRT062607 (P505-15, BIIB057) hydrochloride
• Brief DescriptionInhibitors
• Purification97.70%
• Biological ActivityPRT062607 (P505-15, BIIB057) hydrochloride is a novel, highly selective Syk inhibitor with IC50 of 1 nM in cell-free assays, >80-fold selective for Syk than Fgr, Lyn, FAK, Pyk2 and Zap70.
• Target NameFLT inhibitor; MLK inhibitor; Src inhibitor; Syk inhibitor
• CAS No. 1370261-97-4
• Calculated MW 429.91
• Formulation C19H23N9OHCl
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cardiovascular System
  SMILES:C1CC[C@H]([C@H](C1)N)NC2=NC=C(C(=N2)NC3=CC=CC(=C3)N4N=CC=N4)C(=O)N.Cl
  Pathways:Angiogenesis; MAPK; Tyrosine Kinase/Adaptors
  Receptor:FLT3; MLK1; FGR; Yes; Syk
  Boling pt:
  Melting pt:
  Solubility:Water: 86 mg/mL (200.04 mM); DMSO: 86 mg/mL (200.04 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Coffey G, et al. J Pharmacol Exp Ther, 2012, 340(2), 350-359.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting