• Product NameBMS-777607
• Brief DescriptionInhibitors
• Purification99.89%
• Biological ActivityBMS-777607 is a Met-related inhibitor for c-Met, Axl, Ron and Tyro3 with IC50 of 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM, 40-fold more selective for Met-related targets versus Lck, VEGFR-2, and TrkA/B, and more than 500-fold greater selectivity versus all other receptor and non receptor kinases.
• Target Namec-Met/HGFR inhibitor; TAM Receptor inhibitor
• CAS No. 1025720-94-8
• Calculated MW 512.89
• Formulation C25H19ClF2N4O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Endocrine system
  SMILES:CCOC1=C(C(=O)NC2=CC(F)=C(OC3=C(Cl)C(N)=NC=C3)C=C2)C(=O)N(C=C1)C1=CC=C(F)C=C1
  Pathways:Tyrosine Kinase/Adaptors
  Receptor:Met; RON; AXL; Mer; Tyro3
  Boling pt:
  Melting pt:
  Solubility:DMSO: 47 mg/mL (91.63 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Schroeder GM, et al. J Med Chem, 2009, 52(5), 1251-1254.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting