• Product NameFTI 277 hydrochloride
• Brief DescriptionInhibitors
• Purification97.57%
• Biological ActivityFTI 277 hydrochloride is the methyl ester of FTI 277, which is a potent and selective farnesyltransferase (FTase) inhibitor with IC50 of 500 pM, about 100-fold selectivity over the closely related GGTase I.
• Target NameTransferase inhibitor
• CAS No. 180977-34-8
• Calculated MW 484.07
• Formulation C22H30ClN3O3S2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Metabolism system
  SMILES:COC(=O)[C@H](CCSC)NC(=O)C1=C(C=C(C=C1)NC[C@H](CS)N)C2=CC=CC=C2.Cl
  Pathways:Metabolism
  Receptor:Farnesyl transferase (FTase); GGTase I
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 14 mg/mL warmed (28.92 mM); Water: 17 mg/mL (35.11 mM); DMSO: 96 mg/mL (198.31 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Lerner EC, et al. J Biol Chem. 1995, 270(45), 26802-26806.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting