• Product NameIWP-2
• Brief DescriptionInhibitors
• Purification99.27%
• Biological ActivityIWP-2 is an inhibitor of Wnt processing and secretion with IC50 of 27 nM in a cell-free assay, selective blockage of Porcn-mediated Wnt palmitoylation, does not affect Wnt/β-catenin in general and displays no effect against Wnt-stimulated cellular responses.
• Target NameWnt/beta-catenin inhibitor
• CAS No. 686770-61-6
• Calculated MW 466.6
• Formulation C22H18N4O2S3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC1=CC2=C(C=C1)N=C(NC(=O)CSC1=NC3=C(SCC3)C(=O)N1C1=CC=CC=C1)S2
  Pathways:Cytoskeletal Signaling; Stem Cells
  Receptor:Wnt
  Boling pt:
  Melting pt:
  Solubility:DMF: 22 mg/mL warming (47.14 mM); DMSO: 4 mg/mL warming (8.57 mM)
  Appearance:Gray Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Chen B, et al. Nat Chem Biol, 2009, 5(2), 100-107.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting