• Product NamePalomid 529 (P529)
• Brief DescriptionInhibitors
• Purification98.59%
• Biological ActivityPalomid 529 (P529) inhibits both the mTORC1 and mTORC2 complexes, reduces phosphorylation of pAktS473, pGSK3βS9, and pS6 but no effect observed on pMAPK or pAktT308. Phase 1.
• Target NamemTOR inhibitor
• CAS No. 914913-88-5
• Calculated MW 406.43
• Formulation C24H22O6
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:COC1=CC=C(COC2=C(OC)C=C3C(OC(=O)C4=C3C=CC(=C4)C(C)O)=C2)C=C1
  Pathways:PI3K/Akt/mTOR signaling
  Receptor:mTORC1; mTORC2
  Boling pt:
  Melting pt:
  Solubility:DMSO: 81 mg/mL (199.29 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Xue Q, et al. Y Res, 2008, 68(22), 9551-9557.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting