• Product NameSL-327
• Brief DescriptionInhibitors
• Purification99.50%
• Biological ActivitySL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/ 0.22 μM, no activity towards Erk1, MKK3, MKK4, c-JUN, PKC, PKA, or CamKII;capable of transport through the blood-brain barrier.
• Target NameDNA/RNA Synthesis inhibitor; MEK inhibitor
• CAS No. 305350-87-2
• Calculated MW 335.35
• Formulation C16H12F3N3S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:C1=CC=C(C(=C1)/C(=C(\N)/SC2=CC=C(C=C2)N)/C#N)C(F)(F)F
  Pathways:DNA Damage/DNA Repair; MAPK
  Receptor:AP-1; MEK1; MEK2
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 7 mg/mL (20.87 mM); DMSO: 4 mg/mL (11.92 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Scherle PA, wt al. J Biol Chem. 2000, 275(47), 37086-37092.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting