• Product NameTAK901
• Brief DescriptionInhibitors
• Purification98.18%
• Biological ActivityTAK-901 is a novel inhibitor of Aurora A/B with IC50 of 21 nM/15 nM. It is not a potent inhibitor of cellular JAK2, c-Src or Abl. Phase 1.
• Target NameCDK inhibitor; JAK inhibitor; Src inhibitor
• CAS No. 934541-31-8
• Calculated MW 504.64
• Formulation C28H32N4O3S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CCS(=O)(=O)C1=CC=CC(=C1)C1=CC(C(=O)NC2CCN(C)CC2)=C(C)C2=C1C1=CC(C)=CN=C1N2
  Pathways:Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
  Receptor:CLK2; JAK3; c-Src; FGR; Yes1
  Boling pt:
  Melting pt:
  Solubility:DMSO: 101 mg/mL (200.14 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Pamela Farrell, et al, AACR, 2009, Abstract B270

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting