• Product NameNocodazole
• Brief DescriptionInhibitors
• Purification99.91%
• Biological ActivityNocodazole is a rapidly-reversible inhibitor of microtubule polymerization, also inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM in cell-free assays, respectively.
• Target NameBcr-Abl inhibitor; Microtubule Associated inhibitor
• CAS No. 31430-18-9
• Calculated MW 301.32
• Formulation C14H11N3O3S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:COC(=O)NC1=NC2=C(N1)C=C(C=C2)C(=O)C1=CC=CS1
  Pathways:Angiogenesis; Cytoskeletal Signaling
  Receptor:Abl; Abl (E255K); Abl (T315I); microtubule
  Boling pt:
  Melting pt:
  Solubility:DMSO: 7mg/ml(23.23 mM);Water: <1mg/ml;Ethanol: <1mg/ml
  Appearance:Gray Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Park H, et al. ChemMedChem. 2012, 7(1), 53-56.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting