• Product NameCyclopamine
• Brief DescriptionInhibitors
• Purification97.00%
• Biological ActivityCyclopamine is a naturally occurring chemical that belongs to the group of steroidal jerveratrum alkaloids. It is a teratogen isolated from the corn lily (Veratrum californicum) that causes usually fatal birth defects. It can prevent the fetal brain from dividing into two lobes (holoprosencephaly) and cause the development of a single eye (cyclopia).
• Target NameHedgehog/Smoothened antagonist
• CAS No. 4449-51-8
• Calculated MW 411.63
• Formulation C27H41NO2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Nervous system
  SMILES:C[C@H]1C[C@@H]2[C@H]([C@H]([C@]3(O2)CC[C@H]4[C@@H]5CC=C6C[C@H](CC[C@@]6([C@H]5CC4=C3C)C)O)C)NC1
  Pathways:GPCR/G Protein; Stem Cells
  Receptor:Smoothened
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 2 mg/mL warmed (4.85 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Vorobyeva AG, et al. J Biol Chem. 2014 Nov 28;289(48):33258-74.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting