• Product NameDaphnetin
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityDaphnetin, a natural coumarin derivative, is a protein kinase inhibitor, inhibits EGFR, PKA and PKC with IC50 of 7.67 μM, 9.33 μM and 25.01 μM, respectively, also known to exhibit anti-inflammatory and anti-oxidant activities.
• Target NameEGFR inhibitor; PKA inhibitor; PKC inhibitor
• CAS No. 486-35-1
• Calculated MW 178.14
• Formulation C9H6O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:OC1=C(O)C2=C(C=CC(=O)O2)C=C1
  Pathways:Angiogenesis; Cytoskeletal Signaling; GPCR/G Protein; JAK/STAT signaling; Tyrosine Kinase/Adaptors
  Receptor:EGFR; PKA; PKC
  Boling pt:
  Melting pt:
  Solubility:DMSO: 35 mg/mL (196.47 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Yang EB, et al. Biochem Biophys Res Commun, 1999, 260(3), 682-685.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting