• Product NameTetrahydroberberine THB
• Brief DescriptionInhibitors
• Purification99.89%
• Biological ActivityTetrahydroberberine is an isoquinoline alkaloid isolated from corydalis tuber; has micromolar affinity for dopamine D(2) (pK(i) = 6.08) and 5-HT(1A) (pK(i) = 5.38) receptors but moderate to no affinity for other relevant serotonin receptors (5-HT(1B), 5-HT(1D), 5-HT(3), and 5-HT(4); pK(i) < 5.00).
• Target Name5-HT Receptor antagonist; Dopamine Receptor antagonist
• CAS No. 522-97-4
• Calculated MW 339.39
• Formulation C20H21O4N
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:COC1=C(OC)C2=C(CC3N(CCC4=CC5=C(OCO5)C=C34)C2)C=C1
  Pathways:GPCR/G Protein; Neuroscience
  Receptor:5-HT; Dopamine
  Boling pt:
  Melting pt:
  Solubility:DMSO: 10 mM
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Pingali S, et al. Acta Crystallogr C Struct Chem. 2015 Apr;71(Pt 4):262-5.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting