- Product NameCDDO(Bardoxolone)
- Brief DescriptionInhibitors
- Purification98.00%
- Biological ActivityCDDO is a synthetic oleanane triterpenoid that blocks the cellular synthesis of inducible nitric oxide synthase and inducible COX-2 in INF-γ-activated mouse macrophages with an IC50?value of 0.4 nM.?By suppressing reactive oxygen and nitrogen species (ROS/RNS) formation, it promotes the cellular control of ROS/RNS levels that would lead to DNA damage associated with tumorigenesis.?In various Y cell lines, CDDO has been shown to specifically inhibit proliferation and induce apoptosis. Mechanism studies revealed that CDDO is a ligand for peroxisome proliferator-activated receptor γ, and also that it induces genes regulated by Nrf2, including heme oxygenase-1 and eotaxin-1, which play a role in antioxidant response element signaling activity
- Target NameNrf2 inhibitor
- CAS No. 218600-44-3
- Calculated MW 491.7
- Formulation C31H41NO4
- Storage 3 years -20˚C powder;2 years -80˚C in solvent;
