• Product NameApremilast (CC-10004)
• Brief DescriptionInhibitors
• Purification98.34%
• Biological ActivityApremilast (CC-10004) is a potent and orally active PDE4 and TNF-α inhibitor with IC50 of 74 nM and 77 nM, respectively.
• Target NamePDE inhibitor
• CAS No. 608141-41-9
• Calculated MW 460.5
• Formulation C22H24N2O7S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Metabolism system
  SMILES:CCOC1=C(C=CC(=C1)[C@@H](CS(=O)(=O)C)N2C(=O)C3=C(C2=O)C(=CC=C3)NC(=O)C)OC
  Pathways:Metabolism
  Receptor:PDE4
  Boling pt:
  Melting pt:
  Solubility:DMSO: 92 mg/mL (199.78 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Man HW, et al. J Med Chem, 2009,52(6), 1522-1524.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting