• Product NameOlaparib (AZD2281, Ku-0059436)
• Brief DescriptionInhibitors
• Purification99.82%
• Biological ActivityOlaparib (AZD2281, KU0059436) is a potent PARP inhibitor with IC50 of 5 and 1 nM for PARP-1and PARP-2, respectively.
• Target NamePARP inhibitor
• CAS No. 763113-22-0
• Calculated MW 434.46
• Formulation C24H23FN4O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:FC1=C(C=C(CC2=NNC(=O)C3=CC=CC=C23)C=C1)C(=O)N1CCN(CC1)C(=O)C1CC1
  Pathways:Chromatin/Epigenetic; DNA Damage/DNA Repair
  Receptor:PARP1; PARP2; PARP2
  Boling pt:
  Melting pt:
  Solubility:Water: 0.002 mg/mL (0.0 mM); DMSO: 86 mg/mL warmed (197.94 mM)
  Appearance:White Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Menear KA, et al. J Med Chem, 2008, 51(20), 6581-6591.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting