• Product NameA-83-01
• Brief DescriptionInhibitors
• Purification97.00%
• Biological ActivityA 83-01 is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 with IC50 values of 12 nM, 45 nM and 7.5 nM, respectively.
• Target NameALK inhibitor
• CAS No. 909910-43-6
• Calculated MW 421.52
• Formulation C25H19N5S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Immunology
  SMILES:CC1=CC=CC(=N1)C1=NN(C=C1C1=CC=NC2=CC=CC=C12)C(=S)NC1=CC=CC=C1
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
  Receptor:ALK4; ALK5; ALK7
  Boling pt:
  Melting pt:
  Solubility:DMSO: > 10 mM
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Tojo M, et al. Y Sci. 2005 Nov;96(11):791-800.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting