• Product NameVE-821
• Brief DescriptionInhibitors
• Purification99.97%
• Biological ActivityVE-821 is a potent and selective ATP competitive inhibitor of ATR with Ki/IC50 of 13 nM/26 nM.
• Target NameATM/ATR inhibitor
• CAS No. 1232410-49-9
• Calculated MW 368.41
• Formulation C18H16N4O3S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CS(=O)(=O)C1=CC=C(C=C1)C1=CN=C(N)C(=N1)C(=O)NC1=CC=CC=C1
  Pathways:DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
  Receptor:ATR
  Boling pt:
  Melting pt:
  Solubility:DMSO: 74 mg/mL (200.86 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Philip M Reaper, et al. Nature Chemical Biology, 7, 428-430 (2011)

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting